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Christiana Care Health System

Research

Abstracts

Limited to 2020 or after:

Thomas A. Raper JD, Lupez K, Cox CA, Esener D, Abrams E, Boyd J, Davison J, Leech S, Ockerse P, Johnson J, Nomura JT, Runyon MS, Hogg M, Melton M, Ferre R, Weekes AJ. Prognostic Value of Right Ventricular Dysfunction Assessments in Determining Low Risk Pulmonary Embolism. Acad Emerg Med 2020;27:S25.

Helfer DR, Helber AR, Ferka AR, Klein DD, Deaner T, Slagle D, White WB, Buckler DG, Mitchell OJ, Fiorilli PN, Isenberg D, Nomura JT, Sigal A, Abella BS. Clinical Factors Associated with Significant Coronary Lesions Following Out of Hospital Cardiac Arrest. Acad Emerg Med 2021;28:S140.

Mink J, Panicker A, Kern A, Subedi K, Nomura JT. Time to Resident Signature Predicts Attending Completion of Ultrasound Documentation. Ann Emerg Med. 2021;78:S132.

Weekes AJ, Raper JD, Thomas AM, Lupez K, Cox CA, Esener D, Boyd J, Nomura JT, Davison J, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, Kelly CP, O’Connell NS. Added Prognostic Value of Right Ventricular Assessments for Low-Risk Pulmonary Embolism. Acad Emerg Med. 2022;29:S31.

Weekes AJ, Raper JD, Thomas AM, Lupez K, Cox CA, Esener D, Boyd J, Nomura JT, Davison J, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, Kelly CP, O’Connell NS. Prognostic Accuracy of Machine Learning vs Points Model for Acute Deterioration After Pulmonary Embolism. Acad Emerg Med. 2022;29:S31.

Weekes AJ, Davison J, Lupez K, Raper JD, Thomas AM, Cox CA, Esener D, Boyd J, Nomura JT, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, Kelly CP, Hernandez J, O’Connell NS. Quality of Life One Month After Acute Pulmonary Embolism in Emergency Department Patients. Acad Emerg Med. 2022;29:S87.

Lupez K, Raper JD, Thomas AM, Coz CA, Esener D, Boyd J, Nomura JT, Davison J, Ockerse PM, Leech S, O’Connell NS, Johnson J, Abrams E, Murphy K, Kelly CP, Weekes AJ. Electrocardiographic Patterns Associated with Acute Clinical Deterioration After Acute Pulmonary Embolism. Acad Emerg Med. 2022;29:S118.

Weekes AJ, Raper JD, Lupez K, Cox CA, Thomas AM, Boyd J, Johnson J, Esener D, Abrams E, Ockerse PM, Kelly CP, Nomura JT, Murphy K, Leec S, Davison J, O’Connell NS. Low-Risk Reclassification for Acute Clinical Deterioration After Pulmonary Embolism by Pulmonary Embolism Short-Term Clinical Outcomes Risk Estimation vs Simplified Pulmonary Embolism Severity Index. Acad Emerg Med. 2022;29:S146.

Esener D, Weekes A, Raper J, Lupez K, Thomas AM, Cox C, Boyd J, Nomura JT, Davison J, Ockerse P, Leech S, Johnson J, Abrams E, Kelly C, Norton HJ. Development and Validation of a Prognostic Tool: Pulmonary Embolism Short-Term Clinical Outcomes Risk Estimation (PE-SCORE). J Ultrasound Med. 2022;41:S96.

Mink JT, Panicker AT, Deo S, Kern A, Subedi K, Nomura JT. Time to Resident Signature Predicts Attending Completion of Ultrasound Documentation. J Ultrasound Med. 2022;41:S107.

Cook A. Schneider L, Perza M, Nomura J, Rosini J. Evaluation of Alteplase Infusion Delay Following Bolus and Impact on Outcomes in Ischemic Stroke. Crit Care Med. 2023;S1:S252.

Isenberg D, Herres JP, Zhao H, Cooney DR, Kuc A, Kraus CK, Sigal A, Brandler ES, Ackerman D, Mullen MT, Nomura JT, Gentile NT for OPUS-REACH. Receipt of Intravenous Thrombolysis is Strongly Associated with 90 Day Functional Outcomes for Large Vessel Occlusion Stroke Patients Undergoing Endovascular Therapy. Stroke. 2023;54:ATMP39.

Kuc A, Isenberg D, Ackerman D, Cooney DR, Herres J, Zhao H, Sigal A, Krause C, Brandler ES, Mullen MT, Nomura J, Gentile NT for OPUS-REACH. Factors Affecting Door-in-door-out Times Among Patients Transferred from Non-Endovascular Stroke Centers for Endovascular Therapy. Stroke. 2023;54:AWMP52.

Isenberg D, Sigal A, Kraus CK, Ackerman DA, Brandler ES, Mullen MT, Kuc A, Herres J, Nomura J, Cooney DR, Zhao H, Gentile NT for OPUS-REACH. Door-in-door-out Time is Not Related to Outcomes in Large Vessel Occlusion Stroke. Stroke. 2023;54:ATP37.

Isenberg DL, Brandler E, Cooney DR, Wojcik S, Kuc A, Nomura JT, Murphy KA, Kraus CK, Shahan JB, Herres J, Sigal A, Deaner T, Ackerman D, Zhao H, Mullen M, Gentile NT. Delay in Arrival is Primary Reason Patients with Large Vessel Stroke Do Not Receive Thrombolysis. AEM 2023; 30:91.


MULTICENTER STUDY PUBLICATIONS: Collaborative Investigator (Not on main author line)
Ginsberg MD, Palesch YY, Mill MD, Martin RH, Moy CS et al. High-Dose Albumin Treatment for Acute Ischaemic Stroke (ALIAS) Part 2: A Randomized, Double Blind, Phase 3, Placebo Controlled Trial. Lancet Neurol 2013;12:1049-1058. PMID: 24076337.

Johnston CS, Easton JD, Farrant M, Barsan W, Conwit RA, et al. Clopidogrel and Aspirin in Acute Ischemic Stroke and High Risk TIA. N Engl J Med 2018;379:215-225. PMID: 29766750.

Khatri P, Kleindorfer DO, Devlin T, Sawyer RN, Starr M et al. Effect of Alteplase vs Aspirin on Functional Outcome for Patients with Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial. JAMA 2018;320:156-166. PMID: 29998337.

Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, et al. Thrombectomy 6 to 24 Hours After Stroke with a Mismatch between Deficit and Infarct. NEJM. 378;11-21. PMID: 29129157.

Tillman H, Johnston SC, Farrant M, Barsan W, Elm JJ, et al. Risk for Major Hemorrhage in Patients Receiving Clopidogrel and Aspirin Compared with Aspirin Alone After Transient Ischemic Attack or Minor Ischemic Stroke. Jama Neurol 2019;76:774-782. PMID: 31034032.

Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, et al. Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. N Engl J Med 2019; 381;2103-2113. PMID: 31774955.

Chamberlain JM, Kapur J, Shinnar S, Elm J, Holsti M et al. Efficacy of Levetiracetam, Fosphenytoin and Valproate for Established Status Epilepticus by Age Group (ESETT): A Double Blind, Responsive Adaptive, Randomised Controlled Trial. Lancet 2020;395:1217-1224. PMID: 32203691.

Asdaghi N, Romano JG, Gardener H, et al. Thrombolysis in Mild Stroke: A Comparative Analysis of the PRISMS and MaRISS Studies. Stroke 2021;epub ahead of print. https://doi.org/10.1161/STROKEAHA.120.03346. PMID: 34496619.

Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW; VICTAS Investigators. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. JAMA. 2021 Feb 23;325(8):742-750. doi: 10.1001/jama.2020.24505. Erratum in: JAMA. 2021 Sep 21;326(11):1072. PMID: 33620405; PMCID: PMC7903252.

Williams Roberson S, Nwosu S, Collar EM, Kiehl A, Harrison FE, Bastarache J, Wilson JE, Mart MF, Sevransky JE, Ely EW, Lindsell CJ, Jackson JC; VICTAS Investigators. Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial. JAMA Netw Open. 2023 Feb 1;6(2):e230380. doi: 10.1001/jamanetworkopen.2023.0380. PMID: 36853612; PMCID: PMC9975932.

Presentations

Limited to 2020 or after:

COVID-19 and the Use of Ultrasound – New Developments in Lung Ultrasound
American Institute of Ultrasound in Medicine, Dec 2020
Webinar Lecture Series

Innovative Teaching Methods & Resources
American College of Emergency Physicians 2020 Scientific Assembly, Emergency Ultrasound Management Course

Artificial Intelligence and Handheld Devices: Is the POCUS Landscape Changing?
American Institute of Ultrasound in Medicine, 2021 Annual
Meeting

Controversies in Emergency Ultrasound: The Debate Rages On
Society of Academic Emergency Medicine, 2021 Annual
Meeting

Hand-Held Ultrasound in a System Wide POCUS
Grand Rounds, The MetroHealth System, 2021-06-17

Echocardiography and Sepsis workshop (hands on workshop)
ChristianaCare 2021 Annual Sepsis Update Conference

Getting Involved with Industry
Panel Member, Society of Clinical Ultrasound Fellowships,
Annual Meeting 2021

Innovative Teaching Methods & Resources
American College of Emergency Physicians 2021 Scientific Assembly, Emergency Ultrasound Management Course

Safety Solutions
American College of Emergency Physicians 2021 Scientific Assembly, Emergency Ultrasound Management Course

Administration, Quality Assurance and Disinfection for AEMUS
ACEP AEMUS FPD Exam Review Course January 2022

Obstetrics for AEMUS
ACEP AEMUS FPD Exam Review Course January 2022

Administration, Quality Assurance and Disinfection for AEMUS
ACEP AEMUS FPD Exam Review Course February 2022

Obstetrics for AEMUS
ACEP AEMUS FPD Exam Review Course February 2022

CEUS for Trauma in the ED
US section Grand Rounds Temple EM Ultrasound April
2022

Controversies in Emergency Ultrasound: The Debate Rages On
Society of Academic Emergency Medicine, 2022 Annual
Meeting

Innovative Teaching Methods & Resources
American College of Emergency Physicians 2022 Scientific Assembly, Emergency Ultrasound Management Course

Safety Solutions
American College of Emergency Physicians 2022 Scientific Assembly, Emergency Ultrasound Management Course

Social Media and EM POCUS
Center for Ultrasound Research and Education, Mass
General Hospital

Changing Face of Global Health Post Pandemic and War (panel moderator)
American Institute of Ultrasound in Medicine 2023
Ultracon

Controversies in Emergency Ultrasound: The Debate Rages On
Society of Academic Emergency Medicine, 2023 Annual
Meeting

Manuscripts

Limited to 2020 or after:

Perza M, Koczirka S, Nomura JT. C1 Esterase Inhibitor for Ace-Inhibitor Angioedema: A Case Series and Literature Review. J Emer Med. 2020;58:e121-e127. PMID: 31843319.

Gandhi PS, Queen R, Stowens J, Nomura JT. Soft Tissue Mass Adjacent to the Heart. Visual Journal of Emergency Medicine. 2020:21:100861. PMID: 32839738.

Miller DL, Abo A, Abramowicz JS, Bigelow TA, Dalecki D, Dickman E, Donlon J, Harris G, Nomura JT. Diagnostic Ultrasound Safety Review for Point of Care Ultrasound Practitioners. JUM. 2020;39:1069-1084. PMID: 31868252.

Teran F, Paradis NA, Dean AJ, Delgado MK, Linn KA, Kramer JA, Morgan RW, Sutton RM, Gaspari R, Weekes A, Adhikari S, Noble V, Nomura JT, Theodoro D, Woo MY, Panebianco NL, Chan W, Centeno C, Mitchell O, Peberdy MA, Abella BS. Quantitative Characterization of Left Ventricular Function During Pulseless Electrical Activity Using Echocardiography During Out-of-Hospital Cardiac Arrest. Resuscitation. 2021;167:P233-241. PMID: 34087419.

Fredette J, Kim T, McHugh D, Gissendaner J, Cherico A, Mapp A, Brennan D, Thundiyil J, Nomura J. A Descriptive Analysis of Emergency Medicine Resident Productivity Over the Course of Training. AEM Educ Train. 2021;S:S44-S48. PMID: 34616972.

Abramowicz JS, Adhikari S, Dickman E, Estroff JA, Harris GR, Nomura J, Silverman RH, Taylor LA, Barr RG. Ocular Ultrasound: Review of Bioeffects and Safety, Including Fetal and Point of Care Perspective. J Ultrasound Med;2021: Epub Ahead of Print. doi: 10.1002/jum.15864 PMID: 34724263.

Gaspari R, Weekes A, Adhikari S, Noble VE, Nomura JT, Theodoro D, Woo MY, Atkinson P, Blehar D, Brown SM, Caffery T, Haines C, Lam S, Lanspa M, Lewis M, Liebmann O, Limkakeng A, Platz E, Moore C, Raio C. Comparison of Outcomes Between Pulseless Electrical Activity by Electrocardiography and Pulseless Myocardial Activity by Echocardiography in Out-Of-Hospital Cardiac Arrest: Secondary Analysis from a Large Prospective Study. Resuscitation. 2021;169:167-172. PMID: 34798178.

Weekes AJ, Raper JD, Lupez K, Thomas AM, Cox CA, Esener D, Boyd JS, Nomura JT, Davison J, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, Kelly C, Norton HJ. Development and validation of a prognostic tool: Pulmonary embolism short-term clinical outcomes risk estimation (PE-SCORE). PLoS One. 2021 Nov 18;16(11):e0260036. doi: 10.1371/journal.pone.0260036. PMID: 34793539.

Kam W, DaJuanica NH, Hernandez AF, Saver JL, Fonarow GC, Smith EE, Bhatt DL, Schwamm LH, Reeves MJ, Matsouaka RA, Khan YM, Unverdorben M, Birminghan MC, Lyden PD, Asimos AW, Altschul D, Schoonover TL, Jumaa MA, Nomura JT, Suri MFK, Moore SA, Lafranchise EF, Olson D, Peterson ED, Xian Y. Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants with Intracranial Hemorrhage Among Patients with Acute Ischemic Stroke Treated with Alteplase. JAMA. 2022;327:760-771. PMID: 35143601.

Helfer D, Helber AR, Ferko AR, Klein DD, Elchediak DS, Deaner TS, Slagle D, White WB, Buckler DG, Mitchell OJL, Fiorilli PN, Isenberg D, Nomura J, Murphy KA, Sigal A, Saif H, Reihart MJ, Vernon TM, Abella BS. Clinical Factors Associated with Significant Coronary Lesions Following Out-Of-Hospital Cardiac Arrest. Acad Emerg Med. 2022:29;456-464. PMID: 34767692.

Raper JD, Thomas Am, Lupez K, Cox CA, Esener D, Boyd JS, Nomura JT, Davison J, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, Kelly C, O’Connell NS, Weekes AJ. Can Right Ventricular Assessments Improve triaging of Low Risk Pulmonary Embolism? Acad Emerg Med. 2022;835-850. PMID: 35289978.

Isenberg DL, Henry KA, Sigal A, Deaner T, Nomura JT, Murphy KA, Cooney D, Wojcik S, Brandler ES, Kuc A, Carroll G, Krauss C, Shahan JB, Herres J, Ackerman D, Gentile NT. Optimizing Prehospital Stroke Systems of Care-Reacting to Changing Paradigms (OPUS-REACH): a pragmatic registry of large vessel occlusion stroke patients to create evidence-based stroke systems of care and eliminate disparities in access to stroke care. BMC Neurol. 2022;22:132. https://doi.org/10.1186/s12883-022-02653-x PMID: 35392840.

Nomura JT, Flannigan M, Liu RB, Theodoro RL. Consensus Terminology for Point of Care Ultrasound Studies with Incomplete Documentation and Workflow Elements. Pocus J 2022;7:116-117. DOI: https://doi.org/10.24908/pocus.v7i1.15017. PMID: 36896278.

Weekes AJ, Raper JD, Thomas AM, Lupez K, Cox CA, Esener D, Boyd JS, Nomura JT, Davison J, Ockerse PM, Leech S, Abrams E, Kelly C, O'Connell NS. Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism. Acad Emerg Med. 2022;29:1185-1196. PMID: 35748352.

Haidar DA, Peterson WJ, Minges PG, Carnell J, Nomura JT, Bailitz J, Boyd JS, Leo MM, Liu EL, Duanmu Y, Acuna J, Kessler R, Elegante MF, Nelson M, Liu RB, Lewiss RE, Nagdev A, Huang RD. A Consensus List of Ultrasound Competencies for Graduating Emergency Medicine Residents. AEM E&T. 2022;6:E10817. DOI https://doi.org/10.1002/aet2.10817
PMID: 36425790.

Isenberg DL, Kraus CK, Henry KA, Ackerman D, Cooney DR, Brandler E, Kuc A, Nomura JT, Herres J, Sigal A, Simon K, Mylin K, Gentile NT. Evolution of Endovascular Stroke Centers and Disparities in Access to Stroke Care in the Four Northeastern States: 2015-2019. J Stroke Cerebrovasc Dis 2023;32:106874epub. DOI: 10.1016/j.jstrokecerebrovasdis.2022.106874 PMID: 36469981.

Weekes AJ, Davison J, Lupez K, Raper JD, Thomas AM, Cox CA, Esener D, Boyd JS, Nomura JT, Murphy K, Ockerse PM, Leech S, Johnson J, Abrams E, Kelly C, O'Connell NS. Quality of life one month after acute pulmonary embolism in emergency department patients. Acad Emerg Med. 2023 Feb 14. doi: 10.1111/acem.14692. Epub ahead of print. PMID: 36786661.

Matthews PJ, Ader DR, Harrison CK, Ostahowski PJ, Nomura JT. The Safety, Efficacy, and Expediency of Albuterol Nebulizer Administration by BLS Providers. Prehosp Disaster Med. 2023 Apr;38(2):149-152. doi: 10.1017/S1049023X23000249. Epub 2023 Mar 1. PMID: 36856022.

Helber AR, Helfer DR, Ferko AR, Klein DD, Elchediak D, Deaner TS, Slagle D, White WB, Buckler DG, Mitchell OJL, Fiorilli PN, Isenberg DL, Nomura JT, Murphy KA, Sigal A, Saif H, Reihart MJ, Vernon TM, Abella BS. Timing and Outcomes After Coronary Angiography Following Out-of-Hospital Cardiac Arrest Without Signs of ST-Segment Elevation Myocardial Infarction. J Emerg Med. 2023 Mar 28:S0736-4679(23)00007-0. doi: 10.1016/j.jemermed.2023.01.006. Epub ahead of print. PMID: 36997434.

Kuc A, Isenberg DL, Kraus CK, Ackerman D, Sigal A, Herres J, Brandler ES, Cooney DR, Nomura JT, Mullen MT, Zhao H, Gentile NT. Factors associated with door-in-door-out times in large vessel occlusion stroke patients undergoing endovascular therapy. Am J Emerg Med. 2023 Apr 9;69:87-91. doi: 10.1016/j.ajem.2023.04.009. Epub ahead of print. PMID: 37084482.

Weekes AJ, Raper JD, Esener D, Davison J, Boyd JS, Kelly C, Nomura JT, Thomas AM, Lupez K, Cox CA, Ockerse PM, Leech S, Johnson J, Abrams E, Murphy K, O'Connell NS. Comparing predictive performance of pulmonary embolism risk stratification tools for acute clinical deterioration. J Am Coll Emerg Physicians Open. 2023 May 26;4(3):e12983. doi: 10.1002/emp2.12983. PMID: 37251351.


RESEARCH LETTERS:
Nomura JT, Genes N, Bollinger HR, Bollinger M, Reed JF III. Twitter Use During Emergency Medicine Conferences. Am J Emerg Med 2012;30:819-820. PMID 22424992.

Owens TS, Nomura JT, Papas MA, Poole C, Marco D. Alteration of timing of nursing continuing education units for ultrasound guided intravenous education does not increase utilization. Am J Emerg Med. 2016;34:2248-2249. PMID 27641244.


LETTERS TO THE EDITOR:
Hyde RJ, Schmier C, Schofer J, Nomura JT, Sierzenski P. Ultrasonographically Guided Peripheral Intravenous Cannulation. Ann Emerg Med 2010:56;310-311. PMID 20728779.

Nomura JT, Hyde RJ, Schmier CA, Sierzenski PR. Regarding the Oblique View for Central Venous Access. J Emerg Med 2011;40:331-332. PMID 20869833.

Nomura JT, Blanco P, Provenzal A. Reply. J. Emerg Med 2015;51:82-3. PMID 27236245.

Gaspari R. Weekes A. Adhikari S. Noble VE, Nomura JT, Theodoro D, Woo M, Atkinson P, Blehar D, Brown SM, Caffery T, Douglass E, Fraser J, Haines C, Lam S, Lanspa M, Lewis M, Leibmann O, Limkakeng A, Lopez F, Platz E, Mendoza M, Minnigan H, Moore C, Novik J, Rang L, Scruggs W, Raio C. Reply to Letter. Letter to Editor regarding Gaspari and colleague’s Emergency Department Point of Care Ultrasound in out of hospital and in ED Cardiac Arrest. Resuscitation 2017;114:E7-8. PMID 28219757.


PEER REVIEWED NON-PUBMED INDEXED:
Minett DM, Nace JE, Nomura JT. Hypoxic Respiratory Failure due to Phrenic Nerve Palsy from and Interscalene Brachial Plexus Block and Previously Asymptomatic Pulmonary Embolism. Crit Ultrasound J. 2011;3:105-107.

AIUM Bioeffects Committee. Bioeffects Literature Reviews. J Ultrasound Med 2018:37:1053.

AIUM Bioeffects Committee. Bioeffects Literature Reviews. J Ultrasound Med 2019:38:2525-2530.

Patel TD, Stowens JC, Nomura JT. Shortness of Breath Secondary to Denture Aspiration. Visual Journal of Emergency Medicine. 2020:20;100788. DOI https://doi.org/10.1016/j.visj.2020.100746.

Shanahan EG, Kreider DL, Matthews PJ, Nomura JT. Beaver Tail Liver Variant and Free Fluid on Abdominal Ultrasound. Visual Journal of Emergency Medicine. 2021; 24:101082. https://doi.org/10.1016/j.visj.2021.101082

Tucker R, Peterson W, Mink J, Taylor L, et al. “Defining an Ultrasound-Guided Regional Anesthesia Curriculum
for Emergency Medicine.” AEM Education and Training. 2020 Dec 11;5(3):e10557. doi: 10.1002/aet2. 10577.
eCollection 2021 Jul.PMID: 34124505